ESTROGEN DOMINANCE & PROGESTERONE DEFICIENCY

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"If so much of a woman's health depends on a consistent level of progesterone, why does progesterone deficiency occur at (or before) menopause in Western societies? Did Mother Nature make a mistake? Mother Nature did not make the mistake; we did. Many plants (over 5000 known) make sterols that have progesterone producing effects. In nonindustrialized cultures not subjected to xenoestrogens (chemicals or food that mimic estrogens and increase estrogen levels) and whose diets are rich in fresh vegetables of all sorts, progesterone deficiency is rare. Not only do the majority of women in these cultures have healthy ovaries with healthy follicles producing sufficient progesterone, but at (or before) menopause their diets provide sufficient progesterone producing substances to keep their sex drive high, their bones strong, and their passage through (peri-menopause) & menopause uneventful and symptom-free.

Our food supply system uses many processed foods and foods that are picked days, weeks or even months before being sold. Their vitamin (especially vitamin C) content and their sterol levels fall. We do not receive, in our food, the progesterone producing substances our forebears did. A Lancet article reported that the bone mineral density of skeletons from a church in England dating back to 1729 showed better bones at all ages compared to our skeletons of today. It is likely that both exercise and diet had something to do with that.

A drop in progesterone can cause a concurrent drop in corticosteroid production, leading to a whole other set of symptoms.

Progesterone is a major precursor of the important corticosteroid hormones aldosterone and cortisol, made in the adrenal cortex. These corticosteroids are not made via any other hormone pathway. They are responsible for mineral balance, sugar control, and response to stresses of all sorts, including trauma, inflammation, and emotional stress. A lack of corticosteroids can lead to fatigue, immune dysfunction, hypoglycemia, allergies, and arthritis. Not infrequently, progesterone supplementation effectively resolves these problems.

The adrenal cortex is also capable of making progesterone, principally for its precursor role in making corticosteroids, but many women are so stressed out trying to work, raise children, and be wives that by the time they're in their mid to late thirties or early forties their adrenal glands have nothing left to give. My guess is that when Western women stop making progesterone in their ovaries and their adrenal cortex and brain need to pick up 100 percent of that function to produce corticosteroids, there isn't much progesterone left over for other functions, such as balancing estrogen levels. The adrenals of many women in Western cultures are so depleted they can't even make enough progesterone to make the corticosteroids. This may be an important factor in chronic fatigue syndrome, which is so common in women in their mid-thirties and early forties." ₁

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Below are the test results of a 46 year old pre-menopausal female.  She would be described as "Estrogen Dominant" because of her extremely low levels of progesterone. In fact, if you look closely you will see that her progesterone level of 0.04 ng/ml  is well below the lowest level of a normal MALE (0.07 ng/ml).

This female has all the features of "Estrogen Dominance", one of which is, she cannot lose weight even if she starves herself.  This effect is caused by an almost complete deficiency of progesterone which would act in opposition to the estrogens, which in her case are at normal levels.

Estrogens tell the body to store fat for an emergency and progesterone attempts to regulate a normal body fat level.  Without balancing these opposing hormones it is almost impossible to lose weight and feel your best.

Although DHEA was not tested, an educated guess would be that her levels of DHEA are about half of what they were when she was in her mid-20's and supplementation would probably be indicated.

The following recommendations were made by her medical advisor:

1. Use a USP grade progesterone supplement such as Projuvine or Progest-E or both to increase Progesterone levels. Use as directed!

2. Take 50mg of USP grade DHEA orally for two weeks and then take 25mg every other day for 2 weeks and then skip a week.  Resume 25 mg every other day for 3 weeks then recycle.

3. Use one capsule orally of Diindolylmethane  (DIM #75) each morning.  This product exerts a balancing effect on the hormonal balance and allows weight loss to occur when dieting. Continue use after desired weight is obtained.

4. Begin a calorie restricted diet (or life style change) concentrating on lower fat content foods. An overall fat content of 10% -20% is desirable. Do not attempt a high protein diet as this approach may permanently damage your kidneys or even cause death. A high protein diet creates ammonia as a byproduct and if your kidneys cannot filter the excessive ammonia created by a high protein diet then you can die and folks have.  In fact, the second largest weight-loss company some years ago went bankrupt because many of their customers on their high protein diet plan died.

Another kidney damaging effect brought on by a high protein red meat diet can be Gout, which is the inability of the kidneys to filter out Uric acid.  This damage cannot be reversed and you must then take Gout medications for the rest of your life.  Not a fun situation.

5. Re-test these hormones along with DHEA after 60 days.

6. Keep a weight diary, or log, beginning prior to starting this program and weigh yourself once a week upon awakening.  Do not weigh daily or at different times of the day. Do not try to lose weight rapidly.  One or two pounds per week would be excellent.
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Hormone test results from a 46 year old pre-menopausal female taken January 2004

Laboratory test was performed by Pharmasan Labs, CLIA 4 52D0914898; NY Lab PH 4 7426; EIN 39‑1841640; Medicare Provider # 89065.

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(1) What Your doctor May Not Tell You About Menopause by John R. Lee, M.D.

© 1998-2007 by The Hormone Shop, LLC.

Norman@thehormoneshop.com
This page was last updated on 12/16/07

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